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To research the influence of IKK2 inhibitor VIII (HY-13060, Medchem Convey, Monmouth Junction, NJ) on OA advancement, MLI surgeries were being carried out in twelve-week-previous C57BL/six WT mice. The mice ended up injected with IKK2 inhibitor VIII (2 mg/kg, IP) each individual alternate day for 5 months. OARSI scoring was carried out by blinded